Aversion Technologies, Inc.

Protecting People, Pets and Plants


CAS# 404--86-4, trans-capsaicin

Trans-capsaicin is truly the "gold-standard" for hotness. This highly refined product has few impurities and has been the preferred active for dermal patches and other medicinal uses. Many have reported that trans-capsaicin is more effective than the 95% natural product or nonivamide.


Medicinal and Cosmetic
Trans-capsaicin is used in dermal patches, topical ointments, and creams to relieve minor aches and pains of muscles and joints. Trans-capsaicin is also available in large adhesive bandages that can be applied to the back. It has been reported that a single, hour-long application of a high-concentration trans-capsaicin skin patch provided an average of 19 weeks of sustained reduction in the pain of neuralgia. In fact, one-eighth of the patients in a year-long multi-center, double-blind, randomized clinical trial of a dermal patch experienced such durable pain relief that they never required re-treatment. The others obtained a year of substantial pain relief with four 1-hour dermal applications of the trans-capsaicin patch.

 Concentrations are typically between 0.025% and 0.075%. Research suggests that capsaicin is able to kill prostate cancer cells. The studies showed tumors treated with capsaicin were about one-fifth the size of the untreated tumors. One study suggests capsaicin may be effective against lung cancer cells and researchers in Canada are testing capsaicin as a cure for diabetes.

Food and Beverage
Recently, trans-capsaicin has been added to beverages to 'spice' them up.


Chemical Names 
A) Trans-8-methyl-n-vanillyl-6-nonenamid
B) N-[(4-Hydroxy-3-methoxyphenyl)-8-methyl-6-nonenamide


Product Name:                                trans-Capsaicin
CAS No:                                            404-86-4
Specification:                                    USP 30
Formula:                                           C18 H27 NO3

Appearance    White to Off White Powder
Odor                                                 Very highly pungent and easily penetrating odor
Assay by HPLC 98.0% - 102.0%
Isometric Purity by HPLC (trans) ≥ 94.0% (area) trans-Capsaicin
Isometric Purity by HPLC (cis) ≤ 6.0% (area) cis-Capsaicin
Melting Point 64°C – 67°C
Loss on Drying    ≤1.0%
Residue on Ignition ≤0.1%
Water, %, by KF ≤1.0%

Solubility: Capsaicin in its pure state is poorly soluble in water but soluble in oil